To maximize your chances of winning big at online blackjack, employ these top strategies: First, always learn and use basic strategy charts to make optimal decisions based on your hand and the dealer's upcard. Second, manage your bankroll wisely by setting limits and sticking to them. Third, consider card counting techniques, even in online formats, to gain an edge. Lastly, take advantage of bonuses and promotions to extend your playtime. By combining these strategies, you can enhance your gameplay and increase your potential for significant wins.