The most profitable gambling games often include blackjack, poker, and certain variations of video poker, where skill and strategy can significantly influence outcomes. Blackjack offers a low house edge when played optimally, while poker allows players to compete against each other, making it possible to win based on skill rather than luck. Additionally, games like baccarat and sports betting can also yield high returns, especially for knowledgeable players. Ultimately, the key to profitability lies in understanding the rules, employing effective strategies, and managing bankroll wisely.