Isleta Casino operates 24 hours a day, seven days a week, providing guests with round-the-clock access to gaming, dining, and entertainment options. Whether you're looking to try your luck at the slot machines, enjoy a meal at one of the on-site restaurants, or catch a live show, Isleta Casino ensures that there's always something happening. Special events and promotions may have varying hours, so it's advisable to check their official website or contact the casino for the latest information on specific activities and services.