When playing at online real cash casinos, start by choosing reputable sites with strong security and positive reviews. Always take advantage of welcome bonuses and promotions to maximize your bankroll. Set a budget and stick to it, avoiding chasing losses. Familiarize yourself with the games' rules and strategies, especially for skill-based games like poker. Play games with a lower house edge to increase your chances of winning. Lastly, practice responsible gaming by taking breaks and knowing when to stop, ensuring a fun and safe experience.