As Week 1 of the NFL season kicks off, savvy bettors are eyeing key matchups for potential value. Look for teams with strong preseason performances, like the Buffalo Bills and Kansas City Chiefs, to cover the spread against their opponents. Additionally, consider betting on the over/under for high-scoring games, particularly those featuring explosive offenses like the Miami Dolphins. With injuries and roster changes still fresh, keeping an eye on line movements and injury reports will be crucial for making informed bets. Week 1 offers a mix of excitement and opportunity for astute NFL bettors.