As Week 1 of college football kicks off, savvy bettors are eyeing key matchups for potential value. Look for teams with strong returning rosters, like Alabama and Ohio State, to cover the spread against lesser opponents. Additionally, consider betting on underdogs with solid defenses, such as Oregon State, who could surprise favored teams. Weather conditions and injury reports will also play a crucial role in shaping bets. With the excitement of a new season, Week 1 offers a prime opportunity to capitalize on early trends and make informed wagers.