When exploring the best slot payouts at online casinos, players should focus on Return to Player (RTP) percentages, which indicate the average payout over time. High RTP slots, typically above 95%, offer better chances of winning. Additionally, progressive jackpots can provide life-changing payouts, though they may have lower RTPs. It's essential to research and compare different games, as well as read player reviews, to find slots that not only entertain but also maximize potential returns. Always remember to gamble responsibly and enjoy the experience!