To maximize your chances of winning at online casino slots, start by choosing games with high return-to-player (RTP) percentages, ideally above 95%. Set a budget and stick to it, ensuring you only play with money you can afford to lose. Take advantage of bonuses and promotions, as they can boost your bankroll. Familiarize yourself with the game’s rules and paytable to understand potential payouts. Finally, practice responsible gaming by knowing when to walk away, whether you're ahead or behind, to maintain a fun and enjoyable experience.