Niners Spread is a popular betting strategy used in sports wagering, particularly in football, where the San Francisco 49ers are a prominent team. This approach involves betting on the point spread, which levels the playing field between two teams by assigning a margin of victory. Bettors wager on whether the favored team, in this case, the 49ers, will win by more than the spread or if the underdog will keep the game close. This strategy adds excitement to the game, as it focuses on the margin of victory rather than just the final score.