As NFL Week 6 approaches, savvy bettors are eyeing key matchups for their best bets. The clash between the Kansas City Chiefs and the Buffalo Bills promises high-scoring action, making the over/under an enticing option. Additionally, the San Francisco 49ers' strong defense against a struggling offense like the Atlanta Falcons could lead to a solid spread bet. Keep an eye on injury reports, as they can significantly impact line movements and betting strategies. With a mix of powerhouse teams and potential upsets, Week 6 offers plenty of opportunities for smart wagering.