As NFL Week 1 kicks off, bettors are eager to capitalize on the excitement of a new season. Key matchups, player performances, and team dynamics create a thrilling landscape for wagering. Early lines often reflect offseason changes, making it crucial for bettors to analyze rosters and preseason trends. Popular bets include point spreads, over/under totals, and moneylines, with many looking to back favorites or find value in underdogs. With the unpredictability of the first week, savvy bettors will keep a close eye on injury reports and weather conditions to make informed decisions.